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KMID : 0861120140180020101
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Korean Journal of Oriental Preventive Medicine
2014 Volume.18 No. 2 p.101 ~ p.113
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Effects of Ephedra Herba ethyl-acetate fraction on high fat diet induced hyperlipidemic mice
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Ha Tae-Hoon
Kweon Tae-Woo
Kim Young-Kyoon
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Abstract
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Objective : Ephedra Herba has been widely used for patients with common cold, asthma in eastern countries,especially china japan and korea. Recently it has been also used for obesity in clinic with high frequency. This study was designed to investigate the effects of Ephedra Herba ethyl-acetate fraction (EEAF) onhyperlipidemic mice.
Method : Effects on total cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serumwere measured in this experiment, and in addition, histopathological and gene expression changes in livertissue was also observed.
Results : In our study, EEAF did not affect weight gain in hyperlipidemic mice. Oral administration of EEAFlowered levels of total cholesterol which were elevated by induction of hyperlipidemia. And administrationof EEAF lowered fasting blood glucose significantly. By carrying out ontological analysis, large numbers ofgenes were identified in up or down regulated genes. The expression of the genes that were altered in responseto high-fat diet was restored to normal levels in EEAF treated mice, with a recovery rate of 49%. And it was considered that fatty acid metabolism was one of important key pathway of the recovery.
Conclusion : Results in our study suggest that EEAF can prevent obese and through regulation of dyslipidemiaand hyperglycaemia.
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KEYWORD
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Ephedra Herba, ethyl-acetate fraction, hyperlipidemia
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